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Title: The induction of subsets of MUP genes in the liver by different patterns of GH administration
Author: Johnson, Deborah L.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1991
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Group 1 major urinary protein (MUP) genes can be divided into subgroups named Mup-1.1A, Mup-1.1B, Mup-1.1C and Mup-1.1D. Allelic genes in Balb/c and C57BL/6 inbred strains of mice are referred to as Mup1.1A{2/} and Mup-1.1A{b/} respectively. Expression of MUP genes in the liver is sexually dimorphic, however, the relative expression in males and females varies between subgroups and between allelic genes within a subgroup. Genes from two subgroups, Mup-1.1A and Mup-1.1C code for proteins which are synthesized at higher levels in male than female liver. In contrast, genes from two other subgroups, Mup-1.1B and Mup-1.1D code for proteins synthesized in male liver but undetectable in female liver. The Mup-1.1C subgroup contains two single copy allelic genes, Mup-1.1C{a/} and mup-1.1C{b/}. In C57BL/6 expression of Mup-1.1C{b/} in the liver of males is twice as high as females, whereas in Balb/c, expression of Mup-1.1{Ca}/ in males is seven to twenty times as high as females. Several genes in the Mup-1-B subgroup differ between Balb/c and C57BL/6 mice, however, expression in the liver of these genes is the same in both strains and is approximately one hundred times higher in males than females. In the livers of growth hormone (GH) deficient lit/lit C57BL/6 mice MUP mRNA levels are approximately one hundred fold lower than in phenotypically normal lit/+ C57BL/6 males. The sexually dimorphic pattern of MUP expression is also absent. Administration of GH to male lit/lit mice by one regime caused a large increase in the levels of particular MUP mRNAs in the liver, whereas administration by another regime did not. Altering the GH regime affected some MUP mRNAs more than others.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available