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Title: A clinical and experimental investigation into the effects of occlusive dressings on wound contraction
Author: James, M. I.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1992
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Wound contraction is a component of normal wound healing which is often excessive in split skin grafted wounds. This manifests as extreme scarring which is responsible for the poor cosmetic and functional results seen when split skin grafts are used, for example, in the treatment of burns. This thesis proposes to test the hypothesis that the contraction characteristics of different types of wounds can be affected when they are covered with an occlusive dressing. The work is divided into several sections, each studying a different type of wound. The first study objectively assesses whether the effect of occlusive dressings on human open wound contraction is similar to that in published work using open wounds in rats. In the second section a new animal model is created using bilateral split skin grafted wound on a flexor and non-flexor surface of a rat. This model allows the measurement of the moisture vapour transmission from these wounds, their surface areas and the underlying myofibroblast cell number. Each animal required to produce sufficient objective data for statistical analysis. The third study investigates the effect of an occlusive dressing on the contraction of human split skin grafted wounds. Patients with bilateral upper limb tattoos excised and split skin grafted will be studied. The surface area of one wound (occlusively dressed) will be compared to that of the conventionally dressed wound on the other limb. The final section summarises and analyses the experimental results in the light of contemporary publications. Conclusions and suggestions for further studies are presented.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available