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Title: Near-infrared spectroscopic diagnosis of acute compartment syndrome
Author: Hope, Matthew J.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2008
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Hypothesis: NIRS can be used as a reliable method for the detection of an acute compartment syndrome. Methods:  1) A prospective clinical trial of 102 patients at risk of an ACS. Continuous invasive pressure and NIRS measurements were recorded and compared. 2) A porcine model of 15 animals to investigate the influence of a subcutaneous and intra-muscular haematoma on the ability of NIRS to detect an ACS. 3) Two studies of volunteer subjects investigated the relationship between adipose thickness, measured by ultrasound, and the values of StO2 provided by NIRS. Results: 1) Correlation was observed between StO2 and compartment pressure. Calculating the StO2 difference between the injured and un-injured limbs reduced the inter-patient variability. 2) The presence of a sub-cutaneous haematoma increased the StO2 value. 3) The StO2 value over the leg correlated with adipose thickness and total tissue haemoglobin. Conclusions: Inter-patient variations in StO2 made interpretation of clinical data difficult. The presence of a subcutaneous haematoma could cause a false negative diagnosis of ACS by elevating the StO2 value. The quantitative use of NIRS to measure StO2 could be improved by calibrating for adipose thickness.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available