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Title: Published work in the field of tropical epidemiology
Author: Hayes, R. J.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2001
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The submitted publications relate to research on the epidemiology and control of diseases of importance in developing countries, and fall into two main classes. The first consists of research on methodological issues in statistics and epidemiology arising in the course of the field research. The second consists of substantive epidemiological research carried out in collaboration with scientists in developing countries over twenty years. The methodological research includes work on methods for assessing whether the change in a measured value depends on its initial value; alternative measures of diarrhoea morbidity; design issues in vaccine trials; use of the case-control study design to investigate risk factors for severe malaria; the development and validation of verbal autopsy instruments to diagnose cause of death in countries with inadequate vital resignation; studies of the bias resulting from poor methodological quality in randomised controlled trials; and use of attributable fraction methods to estimate the proportion of febrile episodes attributable to malaria and to evaluate alternative malaria case definitions. Design issues in cluster-randomised trials, particularly in the context of HIV intervention trials in developing countries, are also discussed. Among many publications on HIV infection is a key paper discussing the interaction of HIV and other sexually-transmitted disease (STDs). This argued the need for randomised trials of the impact of STD control on the HIV epidemic, and led to the first such trial in Mwanza Region, Tanzania. The Mwanza trial showed that improved STD treatment services resulted in a 40% reduction in HIV incidence in the general population, and that the intervention was highly cost-effective. This was the first randomised trial anywhere in the world to demonstrate the impact of prevention measures on HIV incidence in the general population. Other papers explore risk factors for HIV-1, HIV-2 and other STDs in a range of settings, the interaction of HIV and tuberculosis, the natural history of HIV infection, simulation models of HIV and other STDs, and the use of Herpes simplex virus type 2 infection as a marker of sexual risk behaviour in rural Africa.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Sc.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available