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Title: Essential fatty acids, gastro-duodenal prostaglandin metabolism, and gastric mucosal protection
Author: Grant, Hugh William
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1991
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This thesis examines the hypothesis that dietary essential fatty acids influence gastric prostaglandin metabolism and acid secretion and could modify the natural history of duodenal ulcer. In healthy controls dietary supplementation with linoleic acid resulted in an increase in the mean output of PGE and its main metabolite, a reduction in mean serum gastrin concentration, a fall in acid secretion and an increase in the output of soluble mucus. In a group of patients with healed chronic duodenal ulcers the mean output of PGE was significantly less than that found in the controls, whilst the mean output of the PGE metabolite was higher. Furthermore dietary linoleic acid did not increase prostaglandin output, nor did it affect acid secretion. These findings showed abnormal prostaglandin metabolism in duodenal ulcer, implying increased PGE catabolism and a failure to respond normally to dietary essential fatty acid. Gastric mucosal injury was induced in normal subjects using aspirin and 80% ethanol. Linoleic pre-treatment had no effect upon mucosal injury in either model, questioning the role of endogenous prostaglandins in mucosal protection. The adipose fatty acid profile in duodenal ulcer patients and matched controls was measured since this reflects chronic dietary fatty acid intake. Mean adipose % linoleic acid was significantly decreased in the ulcer group suggesting that dietary essential fatty acids may be important in peptic ulcer.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available