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Title: Cerebral effects of hypoglycaemia in humans
Author: Gold, Ann Elizabeth
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1994
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The effect of acute insulin-induced hypoglycaemia on cognitive function in humans was examined. The principal studies were performed: i) - to examine whether cerebral adaptation to acute neuroglycopenia occurs in normal subjects, ii) - to examine whether the degree of impairment of cognitive function during acute neuroglycopenia is related to the level of cognitive ability of the subject and iii) - to establish whether patients with insulin-treated diabetes, who have impaired awareness of hypoglycaemia exhibit a more severe degree of cognitive impairment during modest hypoglycaemia. In addition to cognitive function testing in patients with impaired awareness, studies of cerebral blood flow during hypoglycaemia were undertaken using Single Photon Emission Tomography (SPET). Mood changes during acute hypoglycaemia were also examined in non-diabetic subjects. During 60 minutes of exposure to moderate hypoglycaemia there was no evidence of short term cerebral adaptation to neuroglycopenia in normal subjects. Cognitive ability did appear to have some influence on cognitive dysfunction during hypoglycaemia: those subjects of lower cognitive ability appeared to suffer a smaller degree of cognitive dysfunction during hypoglycaemia. During acute hypoglycaemia subjects were observed to have marked changes in mood: there was a decrease in hedonic tone, an increase in tense arousal and a decrease in energetic arousal. Diabetic patients with impaired awareness of hypoglycaemia suffered greater and more prolonged cognitive dysfunction during hypoglycaemia than patients with normal awareness.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available