Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.651482
Title: A comparison of the circadian control of locomotor activity and photoperiodism in Drosophila melanogaster, wild-type and period mutants
Author: Gillanders, S. W.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1993
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Abstract:
Mutant Drosophila melanogaster flies with drastically altered free-running periods of locomotor activity (period mutants) were used to investigate the relationship between circadian control of overt rhythm production and photoperiodic time measurement. Comparison of the free-running rhythms of wild-type, short period and long period mutants revealed that alterations in this periodicity resulted from a decrease in the active phase (short period mutant) or an increase in the inactive phase (long period mutant) when compared with wild-type. Light phase response curves were determined for light pulses of different durations which suggested that the mutants also had an altered sensitivity to light. Comparisons of the photoperiodic response of these strains revealed a remarkable similarity from which it was concluded that the period locus is not essential for PPTM but may be involved in a peripheral role. The light PRC data were used to model the CDL of the photoperiodic response in the wild-type, short period and long period mutants and the modelled results did not agree with the experimental ones. A feedback model for photoperiodic time measurement involving two oscillations, a pacemaker controlling overt rhythmicity and weakly coupled to a slave involved in PPTM was shown to replicate the experimental results. In conclusion, although the locomotor activity rhythm and the photoperiodic time measuring system are both governed by circadian oscillators, they are believed to be, at best, weakly coupled together so that the oscillator controlling locomotor activity may play a role in photoperiodism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.651482  DOI: Not available
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