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Title: Studies on feline IgE
Author: Gilbert, Sophie
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1998
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Ten normal cats were immunised with Dermatophagoides farinae (DF) antigen and intradermal skin tests (IDSTs) were performed weekly. Sera from the latter were also assessed for DF-specific IgE by ELISA and PK tests. Detectable DF-specific IgE was induced in all of the 10 cats, however levels were found not to be correlated with the development of positive IDSTs nor with the levels of IgE as assessed by PK tests. Sera from 10 cats with symptoms consistent with atopy, from 15 normal household cats and from 11 laboratory maintained cats were assessed for allergen-specific IgE and IgG to DF by ELISA. Although DF-specific IgE was detectable in all the atopic cats, there was no significant difference between the levels in this group and in the clinically normal household cats. However levels in both these groups were significantly higher than those in the laboratory maintained cats. The influence of vaccination and endoparasitism on the IgE response to a food antigen was assessed in 34 cats. Seventeen kittens experimentally infected with T. cati and 17 parasite-free kittens were dosed with human serum albumin (HSA) daily for 3 weeks. Seven cats from both groups were given two injections of a live attenuated viral vaccine. The group of parasitised cats has significantly higher levels of HSA-specific IgE, IgG and IgA than did the group of parasite-free cats. Vaccinated cats had also higher levels than non vaccinated cats but only in the group of parasite-free cats. None of the cats developed clinical signs of food allergy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available