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Title: Intravascular ultrasound : forward-viewing pulse-echo and Doppler imaging
Author: Gatzoulis, Loukianos
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2000
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This thesis investigates optimal scanning techniques for forward-viewing intravascular ultrasound imaging. Scaled up artery models, made of tissue mimicking material, were used in the first part of this work in order to study the scanning techniques without the need for miniaturisation. A versatile scaled-up scanning system was constructed, and five different pulse-echo scanning patterns were implemented and evaluated. A scanning technique referred to as the rotational scan emerged as the most suitable. Based on this outcome, a small forward-viewing catheter was manufactured for imaging human vessels in vitro. Operating at 30 MHz, it was integrated with an intravascular ultrasound scanner and a radiofrequency data acquisition system. Two and three dimensional data sets were successfully acquired and assessed for a number of carotid and femoral arteries in vitro. The reconstructed images demonstrated the ability of this forward-viewing system, based on the rotational scan, to visualise healthy lumens, bifurcations, thickened atherosclerotic walls and, most importantly, very severe vessel occlusions. At a further stage, the catheter was used for Doppler studies in tissue mimicking flow phantoms simulating cases of healthy and stenosed vessels, in an attempt to overcome sample volume location uncertainties associated with current Doppler wire techniques. The new intravascular Doppler technique was proven capable of providing velocity profiles, colour flow images and flow quantification. The results show that the rotational scan is a very promising technique for implementing a forward-viewing intravascular ultrasound imaging system suitable for anatomical and functional assessment of stenosed vessels and for guidance of both interventional and pharmaceutical therapies. The results of this thesis will provide the basis for future manufacturing research and development in this field.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available