Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650864
Title: Treatment of human lung cancer with interferon and cytotoxic agents
Author: Fergusson, R. J.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1990
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Abstract:
The prognosis for patients with lung cancer remains extremely poor. Newer, more effective treatment regimens are required. In this thesis, the effectiveness of combining human recombinant interferon alpha with various estalished cytotoxic agents was assessed in laboratory models of human lung cancer and a clinical study. The majority of the experimental work was performed on a series of human bronchial carcinoma xenografts established in immune deprived CBA mice. Interferon alone had no cytotoxic effect but appeared to potentiate the activity of various anti-cancer agents in non-small cell tumours. No such effect was seen in two small cell xenografts. Further studies suggested that the dosing schedules of each agent in the combination was important in producing positive effects. The exact mechanisms by which interferon may interact with cytotoxic drugs remains unexplained. It was shown that the results obtained in the xenograft model were not mediated through increased toxicity to the host or by modulation of cell cycle distribution within the tumour cells. Assessment of interferon/drug combinations was also performed using in-vitro models of lung cancer. Significant synergistic interactions were not demonstrated. A pilot clinical study investigating the potential of combined treatment with interferon and Cisplatinum was performed in a group of patients with non-small cell lung cancer. The toxicity of the treatment was predictable and an encouraging response rate was seen.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.650864  DOI: Not available
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