Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650788
Title: Cognitive and facial emotion processing abnormalities among children at-risk for schizophrenia : candidate targets for early identification?
Author: Dickson, Hannah
ISNI:       0000 0004 5357 5852
Awarding Body: King's College London (University of London)
Current Institution: King's College London (University of London)
Date of Award: 2014
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Abstract:
Adults with schizophrenia are characterised by widespread cognitive and emotion dysfunctions. The neurodevelopmental hypothesis of schizophrenia posits that these abnormalities may precede the onset of overt clinical symptoms of illness, with progressive deterioration as individuals approach and transition to first-episode psychosis. The present thesis explored differences in cognitive performance and motor function in the childhood and adolescence of individuals who subsequently developed schizophrenia compared to those who did not, and examined cognitive and facial emotion processing abnormalities among children at-risk for schizophrenia and schizophrenia spectrum disorders. The findings presented in Chapter Four indicate that lower IQ and motor dysfunction, but not poor scholastic achievement, precede the prodromal phase of schizophrenia. Chapter Six provides evidence that at age 9 to 12 years, children presenting with a triad of antecedents of schizophrenia and children with a high familial loading for the disorder displayed diverse cognitive impairments. The results of Chapter Seven indicate that youth presenting with a triad of antecedents of schizophrenia and youth with a positive family history of the disorder exhibit some cognitive deficits that remain stable from 9 to 15 years, some deficits that increase with age, and other early deficits that show recuperation towards levels of typically developing children by 15 years. Finally, Chapter Nine demonstrates that children presenting with multiple antecedents of schizophrenia are characterised by poor facial emotion processing abilities. The findings of the present thesis indicate that children presenting with antecedents of schizophrenia display similar cognitive and facial emotion processing abnormalities to adults with schizophrenia and children with a positive family history of the disorder. However, only longitudinal follow-up of the children examined in the present thesis will establish the extent to which the triad of multiple antecedents is predictive of later psychotic or non-psychotic disorders.
Supervisor: Laurens, Kristin Robyn Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.650788  DOI: Not available
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