Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.650742
Title: The relationship between aortic calcification and osteoporosis in postmenopausal women
Author: Edwards, Sylvia Frances
ISNI:       0000 0004 5357 3742
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2015
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Abstract:
It is widely accepted that both osteoporosis (OP) and cardiovascular disease (CVD) are common conditions and are a major cause of morbidity and mortality within the ageing population. Traditionally they have been viewed as two separate conditions that increase with age and are therefore frequently seen in the same individual. In this large study of 462 postmenopausal women the primary objective is to investigate the relationship between OP and aortic calcification (AC); investigating associations between AC, BMD and regulators of bone remodelling that have been implicated in the pathogenesis of vascular calcification (VC) such as the Wnt signalling pathway. A secondary objective is to investigate the effects of bisphosphonates (BPs) on VC in postmenopausal women with low BMD, in a 2-year randomised controlled trial. This research is clinically important since no therapies are available that can reverse VC. Results will provide valuable information on whether BPs can be used to prevent or decrease AC in addition to improving BMD and reducing fracture risk. An important aspect of this study is to evaluate the novel application of simple, non-invasive imaging techniques for quantifying AC. Two methods including pulse wave velocity (PWV), an ultrasound method of assessing arterial stiffness, and lateral vertebral fracture assessment (VFA) scanning; an imaging method previously validated for the quantification of AC, will be compared to the gold-standard of computed tomography (CT).
Supervisor: Fogelman, Ignac ; Frost, Michelle Lorraine Sponsor: National Osteoporosis Society
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.650742  DOI: Not available
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