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Title: Biotransformations of hydroxylamine derivatives
Author: Eve, Tom S. C.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2007
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The results presented herein represent a programme focussed towards producing a deracemisation system for hydroxylamines. A number of different avenues have been explored. The use of a number of biocatalytic systems was investigated in an attempt to construct a one-pot system. These included a novel application of monoamine N and laccase enzymes. The enantioselective oxidation of hydroxylamine ethers by MAO-N was a novel discovery. A further development is the engineering of a MAO-N variant which displayed improved catalytic activity for a model hydroxylamine ether substrate compared with the parental enzyme. A second research programme lead to the discovery of the applicability of a laccase:mediator system to the oxidation of hydroxylamines. Investigations into oxime reduction systems with reaction conditions that were complementary to the biocatalytic systems were performed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available