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Title: Lymphocyte activity and flow in renal allotransplantation
Author: Evans, C. M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1978
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The lymphocyte is the principle cell responsible for the main events which occur in the transplantation reaction. The activity of the lymphocyte has been studied in two ways. First, effector lymphocytes, sensitised by allografting in rats, have been tested for their ability to kill antigenic cells in vitro. Secondly, lymphocytes injected into allogeneic rats have been studied in their ability to proliferate in presence of antigenic tissues. The flow of lymphocytes after renal allotransplantation has been studied in sheep by measuring the total body lymphocyte flow after thoracic duct cannulation and drainage, and the renal lymphocyte flow by cannulation of the lymphatics leaving a transplanted kidney. Lymphocyte cytotoxicity measured by in vitro cytotoxicity tests has been achieved with sensitised spleen cells against allografts of tumour and kidney but not skin grafts. Lymph node lymphocytes are not effective as cytotoxic cells. The ability of sensitised lymphocytes to proliferate in the presence of antigenic tissue measured by the graft-versus-host popliteal node weight assay has not been proved. This assay does not show the immune competence of lymphocytes injected into either allogeneic or xenogeneic animals. The flow of lymphocytes is markedly increased in the area of a renal allograft and flowing from the graft. This effect is localised to the graft itself and is not reflected in an alteration in the flow of lymphocytes through the whole body. The action of immunosuppressive drugs on lymphocyte flow is also localised to the area of the allografted organ.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available