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Title: The use of pulsed Doppler ultrasound in the evaluation of left ventricular diastolic behaviour
Author: Ettles, D. F.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1992
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Transmitral diastolic blood flow velocities were recorded in 54 healthy volunteers. The effect of respiration and physiological variables on measurements derived from these transmitral recordings were assessed. The effects of respiration on transmitral flow were found to be highly significant. The inherent variability of transmitral flow velocity spectra over time was investigated in 50 unselected patients and the effects of operator and interpretative variation in the recording and analysis of transmitral spectra investigated. Clinically acceptable observer variability for recording and measurement of transmitral flow was observed. Small inherent variation of certain pulsed Doppler parameters was established. The relationship between left ventricular relaxation measured by M-mode echocardiography and pulsed Doppler transmitral flow parameters was examined in 35 healthy subjects. Close correlation was found to exist between early diastolic events measured by the Doppler techniques and rate of diastolic ventricular expansion. Simultaneous recordings of left ventricular diastolic pressure and transmitral diastolic flow were performed in 50 patients undergoing clinical assessment of ischaemic heart disease. While significant correlation was observed between direct pressure measurements and several pulsed Doppler parameters of diastolic flow, reliable clinical prediction of diastolic ventricular pressure using pulsed Doppler velocimetry was not found to be possible.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available