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Title: A study of risk factors for peripheral arterial disease
Author: Donnan, Peter Thomas
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1994
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This thesis set out to consider risk factors, in isolation and in combination, for symptomatic and asymptomatic Peripheral Arterial Disease (PAD), which unlike Coronary Heart Disease, has not been undertaken in a random sample from the general population aged 55-74 years. The results showed that the risk factors in relationship to the Ankle Brachial Pressure Index (ABPI), an indicator of the extent of asymptomatic and symptomatic PAD, differed for men and for women and for smokers and non-smokers. In women smoking was the main risk factor, while blood viscosity and fibrinogen although univariately related to the ABPI, were not independent risk factors. In men who had never smoked, nonHDL cholesterol and diabetes were the important risk factors. In men who had ever smoked there were synergistic effects of smoking on the relationships between the ABPI and fibrinogen, blood viscosity, leisure activity, and energy adjusted vitamin C. Other independent risk factors for men who had ever smoked were diabetes, social class, nonHDL and HDL cholesterol. This suggests that in considering arterial disease, analyses should be carried out separately for men and women and perhaps for smokers and non-smokers. These results indicated that some health education programmes could be aimed at specific groups, such as female smokers. On the other hand dietary programmes to reduce cholesterol level could be aimed at the general population. Finally, the calculation of power and sample size for epidemiological studies showed that the simple two group comparison calculations generally used underestimated the sample size required when adjusting for numerous confounders and when subgroup analyses are likely, as in a cross-sectional study.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available