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Title: Doppler ultrasound measurement of Arterial Wall Motion (AWM)
Author: Dineley, Judith A.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2007
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Arterial Wall Motion (AWM) is of value in evaluating the elasticity of arteries, which is associated with the degree of focal and diffuse arteriosclerosis. A new technique derives AWM using integrated velocity data generated by Tissue Doppler Imaging (TDI) ultrasound. A preliminary in vivo reproducibility study in asymptomatic carotid arteries revealed high inter-measurement variability (Limits of agreement in TDI derived maximum dilation, Mx: 159μm) and several sources of variability. Accuracy assessment was performed in the laboratory with a device based upon a moving plate which mimicked physiological and sinusoidal motion and whose maximum displacement was know to within 3μm. Accuracy in Mx ranging from -3±8% to -23±1% for sinusoidal device motion, with amplitudes ranging from 248-1190 μm was obtained. Underestimation of Mx by the TDI/AWM software was found to systematically increase with increasing sinusoid amplitude and peak velocity. A compliant wall vascular flow phantom with mechanical and acoustic properties similar to tissue was designed for assessment of AWM technique precision. It consisted of a 6mm diameter uniformly elastic vessel of wall thickness 1.73 mm set in gelatin based tissue mimick. Two tissue mimick versions were devised: ‘A’ mimicked soft tissue attenuation for assessment of AWM precision, and ‘B’ maximised backscatter from the vessel. The latter was to optimise TDI/AWM technique performance during phantom characterisation measurements by maximising the signal received at the transducer. A range of realistic dilations and wall velocities were generated with pulsatile flow. AWM precision was found to vary with vessel depth (7±3%), beam-vessel angle (22±3%), scan plane-vessel coincidence (34±2%) and transducer pressure (20±3%).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available