Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649181
Title: The role of prostanoids and kinins in the pharmacotherapy of heart failure
Author: Davie, Andrew P.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2000
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Abstract:
The study in chapter 2 examined the effect of intra-arterial arachidonic acid on forearm blood flow in healthy volunteers and in patients with heart failure treated with an ACE inhibitor. We found that arachidonic acid was vasodilating and that this vasodilation was inhibited by 14 days oral aspirin, even a dose as small as 75mg daily. This does not prove that aspirin adversely effects vascular tone in these patients, but it does prove that it could. The study in chapter 3 examined the effect of aspirin on the immediate venodilator response to intravenous frusemide in patients with heart failure treated with an ACE inhibitor. We found that there was a small immediate venodilator response to intravenous frusemide, and we found that this vasodilator response was inhibited by 14 days oral aspirin, even a dose as small as 75mg daily. This proves that aspirin adversely effects the haemodynamic response to frusemide in these patients. The study in chapter 4 examined the effect of bradykinin and substance P on forearm blood flow in patients with heart failure treated with an ACE-inhibitor, and the effect of aspirin. We found that bradykinin and substance P were potent vasodilators, but that neither was affected by aspirin. This implies that neither bradykinin nor substance P is likely to contribute to a negative interaction between aspirin and ACE inhibitors. The study in chapter 5 examined the effects of bradykinin and its antagonist on forearm blood flow in patients with heart failure randomised to double-blind crossover treatment with ACE inhibitor or AT1 antagonist. Whilst we found that the response to bradykinin was enhanced by ACE inhibitor, as expected, we found no significant effect of bradykinin antagonism with an ACE inhibitor or an AT1 antagonist.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.649181  DOI: Not available
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