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Title: Design and characterisation of nanostructured microelectrodes for biomedical applications
Author: Alshadokhi, Mohammed
ISNI:       0000 0004 5346 890X
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2014
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The aim of the project is to create a nanostructured microelectrode pH sensor to measure the pH of brain fluids. This work will describe the fabrication, characterization and development of the nanostructured Pd electrodes and their assessment for use as pH sensors in the brain fluid. The palladium hydride α+β transition is located between the α and β phases where H/Pd atomic ratios range between 0.02 and 0.6. This region was selected to fabricate the pH sensor because its potential (Epd-H) is stable and independent of the hydrogen– palladium composition. In addition, Epd-H follows a linear relationship with pH. A nanostructured Pd film was chosen to fabricate the pH sensor in order to obtain a large electroactive area because Epd-H is not stable with microelectrode; a large area is needed to reach the equilibrium between palladium and hydrogen. Also, neurobiological pH measurements require a small sensor as a result of the limited biological sample quantities available. The nanostructured pH sensor H1-e Pd was made by liquid crystal templating method (LCT). Scanning electron microscopy (SEM) and electrochemical characterisation were used to estimate the radius a and electroactive area of the nanostructured Pd film after the deposition process. The α+β transition was prepared by loading hydrogen electrochemically before the experiments were carried out. The nanostructured Pd hydride electrode was then used to estimate the pH in different solutions including artificial cerebral spinal fluid (aCSF) and real brain fluid. The results obtained demonstrate the applicability of such electrodes to function as pH sensors in brain fluid. The biomedical applications requires high efficiency that can be affected by the biological samples contaminations onto the electrode. Thus, attempts were made to develop the H1-e Pd pH sensors performance by covering their surface with coats to stop the biological impurities.
Supervisor: Denuault, Guy Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry