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Title: Cyclisation of propargyl and allyl amides : syntheses of oxazolines
Author: Alhalib, Ali
ISNI:       0000 0004 5363 6328
Awarding Body: University of Huddersfield
Current Institution: University of Huddersfield
Date of Award: 2015
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This thesis describes several approaches to the synthesis of dihydrooxazoles (oxazolines) by the cyclisation of unsaturated amides. The first major approach to the synthesis of substituted dihydrooxazoles is the CuI-catalysed cycloisomerisation of terminal propargyl amides. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidised to the ketone under the reaction conditions. The second major focus of this thesis is the cyclisation of N-alkenylamides catalysed by iodoarenes under oxidative conditions. Dihydrooxazoles were prepared by this route with a range of substitution patterns in good yields.
Supervisor: Moran, Wesley Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry