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Title: An investigation of real time ultrasound Doppler techniques for tissue motion and deformation analysis
Author: Criton, Aline Laure
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2006
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The objective of this dissertation research is to develop new techniques based on Doppler ultrasound to investigate and visualize changes in tissue dynamic and deformation properties due to atherosclerosis in cardiac and vascular applications. A new technique, to correct for the Doppler angle dependency for tissue motion analysis has been developed. It is based on multiple ultrasound beams, and has been validated in vitro to study tissue dynamic properties. It can measure tissue velocity magnitude with low bias (5%) and standard deviation (10%), and tissue velocity orientation with a bias less then 5 degrees and a standard deviation below 5 degrees. A new Doppler based method, called strain rate, has also been developed and validated in vitro for the quantification of regional vessel or myocardial wall deformation. Strain rate is derived from the velocity information and can assess tissue deformation with an accuracy of 5% and a standard deviation less than 10%. Some examples of cardiac strain rate imaging have been gathered and are described in this thesis. Strain rate, as all Doppler based techniques, suffers from angle dependency limitation. A method to estimate one-component strain rate in any direction in the two-dimensional image not necessarily along the ultrasound beam has been developed. The method allows correcting for the strain rate bias along any user-defined direction. In vitro experiments have shown that qualitative two-component strain rate tensor can be derived. Two-component vector velocity from the moving tissue was acquired and two two-component strain rate images were derived. The images showed agreement with the expected deformation pattern.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available