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Title: Genetic interactions between lgf2 and p53 during embryonic and tumour development
Author: Haley, Victoria Louise
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2010
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IGF2 and p53 regulate key pathways that modify growth and survival throughout development and cancer. In vitro evidence has suggested there may be significant cross-talk between both pathways. However, it remains unclear whether disruption of these pathways would alter development and tumour formation in the whole organism, particularly because of complex feedback loops and compensatory autoregulation. The aim of this thesis was to evaluate pathway interactions in mouse models with single allelic dose changes of lgf2 and p53 during embryonic and tumour development.
Supervisor: Hassan, Bass Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available