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Title: Genetic aspects of sheep immune response
Author: Ciupercescu, Dumitru-Dorel
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1976
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Genetic aspects of the general regulation of antibody synthesis in sheep were studied together with levels of serum immunoglobulins and other related functions. An initial attempt to estimate the heritability of the size of the cumulated immune responses to two bacterial antigens revealed the necessity to find first an appropriate means to adequately assess the individuals' capacity to mount an humoral response. Using 8 unrelated, natural antigens, administered one at a time in relatively high doses under experimental conditions which allowed to measure and eliminate from the calculations all possible antigenic cross-reactions and other effects (time, breed, sex etc.), it has been shown that there is a strong individual component reflected in a general capacity of animals to respond with high or low antibody production to all antigens used. This so-called individual general immune response capacity was positively correlated with the serum Ig and particularly with IgM levels, but not with the "in vitro" lymphocyte stimulation by FHA. Serum Ig levels showed a high individual variability, but within one individual their levels tend to stay constant for large periods of time, except around lambing when IgOl and IgM levels decrease due to their selective transfer into the colostrum. Even the immunisations showed little direct influence on serum Ig levels. Based on these observations, it appears that serum Ig levels could be used to a certain extent as predictors of the individual general immune response capacity. Aspects concerning genetic resistance to disease are discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available