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Title: A study of soft neurological signs in schizophrenia
Author: Chen, E. Y. H.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2005
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This dissertation describes a series of studies addressing the prevalence, correlates and longitudinal changes in soft neurological signs (SNS) in schizophrenia. SNS have been found to be increased in schizophrenia. The increase appeared to have both a genetic and a non-genetic component. As such it has been proposed that SNS could be considered as one of the biological markers expressing a mediating risk for schizophrenia. In order to clarify the role of SNS in a given perspective it is important to understand factors that affect the expression of SNS in a given population. In the first chapter a broad introduction is presented. Chapter 2 continues with a more detailed review of the existing data about SNS in schizophrenia. Chapter 3 presents the core methodology and assessment instruments used in the studies. In Chapter 4 the recruitment procedures and the characteristics of the samples are described. Data analysis and results are presented in Chapters 5 to 8. In Chapter 5 important correlates of SNS are explored using data from a larger cross-sectional sample of Chinese patients and controls. These include age, gender, education level and intelligence level, as well as symptom correlates of SNS. The potential effects of ethnicity were further explored by comparison between Chinese and Caucasian controls samples. Additional analyses were carried out to attempt to address the relative importance of age and illness duration for SNS in patients. Chapter 6 describes in more detail the relationship between SNS and cognitive functions in this cross-sectional sample. Chapters 7 and 8 describe two longitudinal studies. Chapter 7 deals with a 3-year follow-up study for stable chronic patients. Chapter 8 addresses a 2-year follow-up study of SNS in the first episode patients. In Chapter 9 the dissertation ends with a general discussion of the current findings and suggestions for key areas for future research.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available