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Title: A population study of low birth weight infants, with special reference to impaired fetal growth
Author: Cater, J. I.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1978
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The major aims of this project were, first, to study a cohort of low birth weight infants and their carefully matched controls in order to determine the effects of perinatal disease and social circumstances on subsequent long term performance; and, second, to improve the current definitions of intrauterine growth retardation. The potential contribution to knowledge of this work lies in its prospective design using a clearly defined catchment area and carefully matched individual controls. As a consequence it has been possible to demonstrate significant differences between the maternal backgrounds of low birth weight and control infants and to conclude that low birth weight infants are in the main derived from biological backgrounds inferior to those of their matched controls. My major interest during the study was to improve the definition of intrauterine growth retardation. Analysis of eight different methods presented in Chapter V highlights the difficulties of achieving such an objective. The difficulties arise because of the multiplicity and variety of biological factors which influence fetal growth; these are discussed in the chapters dealing with maternal contribution to fetal growth, outcome of sibling of LBW infant, congenital abnormalities and the corroboration of the last menstrual period by the total 'maturity' score. As a background to the study, the relevant literature is reviewed, and a detailed discussion is presented of the methodological problems encountered in the setting up of a low birth weight study. One section describes several new clinical features related to gestation or fetal growth. Further details are given in a chapter describing a number of neonatal measurements, such as the Apgar score and biochemical data. Lastly, there is a section describing the morbidity pattern in the cohort during infancy and early childhood.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available