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Title: The formation of corticocortical connections in the cat's visual cortex
Author: Caric, Damira
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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The aim of this study was to investigate the postnatal development of association projections in the kitten's visual cortex. New sensitive fluorescent lipophilic tract-tracers were placed side-by-side in area 17 of fixed brains of various ages, from postnatal day 1 to 30. These tracers showed that afferents from area 17 had just reached the deep layers of areas 18 and 19 at birth. A few had entered the cortex, mostly at points that corresponded retinotopically with those of the injection sites. These points were linked by distinct axonal tracts from postnatal day 1 on, suggesting that many corticocortical axons had grown in an ordered fashion between specific points in striate and extrastriate cortex. During the second and third postnatal weeks, corticocortical fibres became increasingly densely distributed in layers 5 and 6 of extrastriate areas. At the same time, more and more axons penetrated the superficial layers, but their tangential distribution was narrower than that of the projections to the deep layers. Confirmation of this more restricted penetration of upper layers came from in vivo injections of retrogradely transported traces: injections restricted to the superficial layers of area 18 labelled a relatively narrower region of area 17 than injections in deeper layers. By the fourth postnatal week, corticocortical afferents in areas 18 and 19 were mainly restricted in patches. At all ages, injections of lipophilic tracers in area 17 retrogradely labelled cells in areas 18 and 19; from birth on, most of these cells were in the same regions where axons from area 17 were penetrating the cortex, indicating reciprocal topography.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available