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Title: Uterine papillary serous carcinoma
Author: Campbell, Hannah
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2008
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The aim of this thesis was to investigate potential mechanisms of invasion of UPSC, using an immunohistochemical approach, using high-grade endometrioid endometrial carcinoma (EEC) as a comparator. An audit of all cases of UPSC diagnosed in South East of Scotland over a 10 year period confirmed the poor prognosis of UPSC and showed that this was conferred even in those cases where the tumour was composed of 5% UPSC regardless of the additional tumour type. It also raised awareness of the need for accurate and complete surgical staging. Tissue microarrays (TMAs) were created from the central viable part of the tumour and the invasive edge of UPSC and EEC and were shown to be valid for studying expression of the markers involved in this study. There was intertumoural variation in expression of E- and P-cadherin, CD98 matrix metalloproteases (MMPs) -2 and -9 and ER and PR in both UPSC and EEC. ER status is known to affect expression of E cadherin, β catenin, CD98 and MMPs-2 and -9, and E cadherin levels were decreased and the other protein molecules all showed higher expression in EEC compared to UPSC. The results are consistent with the role that oestrogen plays in the development of EEC. Intratumoural variation in expression of E cadherin, P cadherin, β catenin, CD98, Galectin-3, MMPs -2 and -9 was demonstrated, supporting the theory of a subclone of the tumour developing properties necessary for invasion. These data contribute to the growing body of literature on UPSC, and address diagnostic and treatment uncertainties for the pathology, surgical and oncological teams.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available