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Title: Blood and protein loss in whole gut lavage fluid in gastrointestinal disease
Author: Brydon, W. Gordon
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1996
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The object of this thesis is to investigate the value of analysis of WGLF in the assessment of Gl pathology, specifically in the measurement of blood and protein loss from the gut. The method for haemoglobin measurement was selected on the basis of a need for sensitivity and the need to detect metabolites of haemoglobin as well as the parent molecule. The measurement of haemoglobin in WGLF has been assessed in a series of patients with clinical conditions known to result in anaemia and which may be related to blood loss from the gut. The relationship between the subjective assessment of inflammatory bowel disease activity and the measurement of WGLF proteins arising by leakage from plasma has been examined with a view to establishing more objective activity indices. The specificity of WGLF protein measurements for the diagnosis of active inflammatory bowel disease has been assessed in a large group of patients with a variety of gastrointestinal pathologies. Gut clearance measurements of plasma proteins and haemoglobin have been undertaken to evaluate quantitative protein and blood loss in normal and pathological groups. Many workers have used alpha-1-antitrypsin in faeces as an indicator of inflammatory bowel disease, and different molecular weight forms have been described. The molecular weight of alpha-1-antitrypsin in WGLF has been investigated in controls and patients with inflammatory bowel disease. Hyaluronic acid, a structural glycoprotein found in the submucosa of the intestine has been determined in WGLF in control and patient groups in an attempt to find a direct index of tissue disruption during active disease process in the gut.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available