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Title: Hepatitis C and G in south east Scotland : studies in epidemiology, progression of disease and quality of life
Author: Blair, Carol S.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2005
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Hepatitis C is now a global health problem with an estimated 170 million people infected worldwide. It is known to be the cause of the majority of cases of non-A, non-B hepatitis. It is known to be progressive with at least 20% of patients developing cirrhosis over 20 years. What is less clear is whether all infected people will eventually develop complications and whether certain factors are important in progression of this disease. The aims of this thesis were to: Study the epidemiology and natural history of HCV infection in our population of HCV infected patients in South East Scotland; Investigate the factors important in progression of chronic HCV infection and also the effects of chronic HCV infection on quality of life; and Examine another novel flavivirus, HGV, in Scottish blood donors. A database of all patients with chronic HCV referred to our hospital was set up. Data was gathered prospectively and analysed with regards to demographic variables and factors related to progression of disease. The importance of HLA status in development and severity of disease was also examined. Finally the impact of chronic HCV infection on QOL was assessed in a subgroup of this population. In a separate population the prevalence, natural history, clinical significance and risk factors for transmission of HGV were assessed. 262 patients were included in the database. Various demographic variables were recorded. Nearly 20% had cirrhosis on biopsy. Factors important in progression were age at infection, male sex and alcohol consumption. When HLA status and progression were examined certain antigens were found to protect against development of chronic disease, significant inflammation and cirrhosis. Quality of life was found to be significantly impaired across all domains of life in patients with chronic HCV infection. HGV is common amongst Scottish blood donors but is not associated with significant symptoms or liver disease. A risk factor for infection was not identified in the majority of infected donors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available