Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.641282
Title: The relationship between hippocampal long-term potentiation and spatial learning
Author: Bannerman, David M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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Abstract:
The aim of this thesis was to further investigate the relationship between hippocampal LTP and spatial learning in the watermaze by assessing (i) the effects on spatial learning of manipulating the inducability of LTP through a different site on the NMDA receptor complex (the glycine site), (ii) the effects on spatial learning of preventing the expression of LTP at a site downstream from the NMDA receptor (the synthesis of the putative retrograde messenger, (NO), and (iii) a further investigation of the effects of AP5 on spatial learning using a different watermaze protocol from those used previously. In a final series of experiments, watermaze-experienced animals, which had been extensively trained, in the absence of any drug treatment, on a standard spatial reference memory task, were infused with either AP5 or artificial CSF and then trained on a spatial reference memory task in a second watermaze, located in a novel spatial environment. Although AP5 treated animals took consistently longer to escape from the pool during training, they were not significantly impaired when assessed using conventional 'transfer test' measures of performance. In contrast, rats with hippocampal lesions were impaired. Subsequent electrophysiological investigations revealed that the AP5 infusion had resulted in a near complete blocked of hippocampal LTP in these animals. Neither 7CK, nor L-NAME, had any effect on the induction of hippocampal LTP in these experiments. Consequently, neither approach enabled us to test the hippocampal LTP/spatial learning hypothesis. In contrast, AP5 infusion did block the induction of LTP but produced only a mild behavioural impairment in the watermaze. The AP5 infused rats were capable of considerable spatial learning, suggesting that the profile of impairment following AP5 treatment is different from that obtained after a hippocampal lesion. This result poses a serious challenge to the hippocampal LTP/spatial learning hypothesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.641282  DOI: Not available
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