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Title: Prostaglandins and utero-ovarian relationships in the sheep
Author: Alwachi, Sabah Naser
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1979
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Previous work on the control of luteal function in the oestrous cycle of sheep is assessed and discussed. The experimental work produced the following conclusions: 1. No difference was found between PGFza and PGFE content and synthesizing ability of the uterine caruncular and non-caruncular endometrial tissue but myometrium contained significantly less and produced less PGFza than did the endometrium. 2. A significantly higher PGF2a content was found in the second half of oestrous cycle. 3. No changes were found either in the content or synthesis of PGE2 and 6-oxo-PGFia in the uterine tissues. 4. Plasma levels of PGFza were episodic and increased on day 12 and 13 of the cycle but reached a maximum on the day after progesterone secretion had ceased. 5. A significant relationship was found between the ability of endometrial tissue to synthesize PGFza and PGE2 and between the endometrial content of PGFza and PGE2. 6. PGFp was found to increase significantly 3 and 2 days before the onset of oestrus in sheep with an ovary adjacent to the uterine horn but not in those animals with the adjacent ovary removed. 7. No relationships was found between plasma levels of PGFza and its endometrial content and synthesis. 8. A significant relationship was found between the concentrations of PGFs and progesterone in the uterine venous blood. This was most demonstrable when PGFza levels were compared with the progesterone levels half-hour previously. 9. The anastomosis of the utero-ovarian vein of a fistulated uterine horn to the anterior mammary vein in the presence of the ovary was found not to interrupt the normal oestrous cycle. 10. A significant concentration of PGFza were found in the oviducal vein, the ovarian vein and the uterine vein when compared to peripheral levels suggesting this as another route in the transfer of PGF2a in addition to the proposed countercurrent mechanism. 11. Daily injection of progesterone to sheep caused accumulation of large amounts of PGF2a rich fluid in the uterus. Higher levels of PGFza than peripherals were also found in the uterine venous blood of the treated animal.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available