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Title: Structural and functional analysis of TREX
Author: Holland, Arthur Ekasatrya
ISNI:       0000 0004 5363 6045
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2015
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The TREX (Transcription-Export) complex is a well-conserved assembly of proteins, which is essential in eukaryotic gene expression. The expression of mRNA involves a number of processing events of primary transcripts to form a mature mRNA. TREX functions at the interface between transcription and export, associating with transcripts at various stages during its processing and packages it into an export-competent mRNP. Export of most mRNAs is dependent on the export receptor, Nxf1. This protein is recruited to the mRNP by directly binding to TREX components. Because the association of TREX with the mRNA is dependent on accurate processing events, it serves as a quality control signal for the recruitment of Nxf1 to promote export. Furthermore, newly identified TREX8 associated factors suggest that TREX could integrate into a wide range of cellular functions and mounting evidence indicates that TREX is essential for the maintenance of genome stability. Aberrations in TREX expression cause harmful RNA:DNA hybrid structures, which are susceptible to DNA damage. TREX therefore, represents an important target for studying the regulation of gene expression.
Supervisor: Wilson, Stuart Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available