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Title: Blood group polymorphisms, mortality and morbidity in newborn babies
Author: Sarfarazi, M.
Awarding Body: University College of Swansea
Current Institution: Swansea University
Date of Award: 1981
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The effect of variation in genotype for blood group polymorphisms on the health and development of a large random sample of babies born in the two major hospitals of Cardiff during 1976-78 were studied. Three blood group systems, ABO, MN, and Rh were assayed together with 18 different birth variables during the first 28 days of life, and with other mortality, morbidity and developmental screening factors up to the age of one year. For both surveys, babies born to two overseas parents were the main source of heterogeneity in the data, and the exclusion of these babies resulted in almost homogeneous data. All blood group systems were found to be similar to those previously recorded for other parts of the U.K., in respect of genotype and phenotype frequencies. In a search for possible associations between blood group phenotypes with both birth and developmental variables, six significant associations were detected. These are, between ABO phenotypes with: age of mother (P = 0.043), smoking habits (P = 0.011), foetal complication (P = 0.044) and sex of infant (P = 0.030), and between MN phenotypes with: maternal height (P = 0.027) and gross motor of the Denver Developmental Screening Tests (P = 0.038). A total of 123 associations were tested in which at the five percent level 6.15 significant results would be predicted by chance alone. 7 tests showed probabilities between 0.5 and 0.10 (inclusive), compared with 6.15 expected by chance alone. Hence the six associations detected here seem likely to be statistical artefacts but the relation of smoking habits to ABO phenotypes might usefully be followed up. In general, however, it seems likely that for the individual loci and both birth variables, and the other factors involved in the mortality, morbidity, and development of the newborn babies studied here, the genetic variation is selectively neutral rather than adaptive. However, since heterozygotes at the ABO and MN loci are more common than expected, it would be profitable to look further into this aspect of the investigation. Associations of congenital abnormalities and foetal complication of labour with 12 other birth variables in the Cardiff Birth Survey were studied. A total of 27 tables were analysed by sets of X2 tests of which 20 showed results significant below the 0.0001 level. These associations are discussed in the Appendix.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available