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Title: Voltammetric investigations of heteroaromatic polymers for immunosensor viable, electrochemical label detection systems
Author: Page, A. B.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2004
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Chapter One provides a brief introduction to immunoassay, historical biosensor development, concepts of electrical conduction in conjugated organic polymers, the electrochemistry of carbazolyl pendant polymers, cyclic voltammetry, and semi-empirical molecular modelling, as applied in this thesis. Chapter Two describes the use of cyclic voltammetry to assess the viability of an electrochemical host:guest detection sensor based on carbazole:dinitrobenzene charge transfer complexes. Proton nuclear magnetic resonance and ultra-violet/visible spectroscopic techniques were also investigated to establish the stoichiometry of solution equilibria, association constants, and standard free energy changes for these complexes. Semi-empirical molecular modelling rationale was also explored. Chapter Three encompasses an investigation into the comparative electrochemistry of carbazolyl pendant polymers variant in “spacer” type and “core” size. The diffusion efficiency of counterions within each cross-linked polymer, and potential charge transfer pathways are also assessed. In addition, electrochemical re-examination of previously reported host:guest inclusion chemistry involving carbazolylalkyl-β-cyclodextrin style pendant polymers is reported. Semi-empirical molecular modelling rationale was also explored. Chapter Four incorporates an investigation into the viability of electroactive, single chain, heteroaromatic polymers exhibiting a distinct ionic charge, for applications into simple, ionic charge effecting label detection. Attempts were made to electropolymerise readily available monomeric compounds, to synthesize new compounds, and to formulate relevant co-polymers and composite polymers.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available