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Title: Synthesis and chemiluminescent properties of novel chemiluminescent compounds
Author: Li, Z.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 1999
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Radioactive isotopes have been very important labelling materials in biochemistry and medicine since the 1940s. Their high detection sensitivity renders them extremely useful. However, their hazardous, limited shelf life and the difficulty of production are disadvantages. As potential substitutes for radioactive isotopes, acridinium compounds can be detected sensitively by measuring the light emitted from their reaction with hydrogen peroxide. Acridinium esters are apparently safe and can be synthesised in any laboratory in gram quantities. In addition, the unique chemiluminescent properties (multifarious wavelengths and lifetimes) of acridinium esters enable them to be used in some new analytical techniques like multiple-analyte assays. Structural factors are important to the chemiluminescent properties of acridinium esters. Therefore, the research presented in this thesis involves a) synthesis of new acridinium esters by structural modification of both the acridine ring and the phenoxy ring, and b) investigation of the effects of these modifications on the chemiluminescent properties of the acridinium esters. The first chapter gives the background of the project. The remaining chapters (chapter 2-8) detail the syntheses of twelve chemiluminescent compounds for example 2-methoxy-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinum-9-carboxylate trifluoromethanesulfonate 1, 2,6-dimethoxy-4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium 9-carboxylate trifluoromethanesulfonate 2, 3-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulfonate 3, 4-(2-succinimidyloxycarbonylethyl)phenyl 2,7-diisopropyl-10-methylacridinium-9 carboxylate trifluoromethanesulfonate 4, 4-(benzyloxycarbonylethyl)phenyl 2,7-dimethoxy-10-methylacridinium-9-carboxylate trifluoromethanesulfonate.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available