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Title: Studies on the effects of some gonadal hormones on different models of 'aggression' in laboratory albino mice (Mus musculus L.)
Author: Kamis, A. B.
Awarding Body: University College of Swansea
Current Institution: Swansea University
Date of Award: 1983
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Abstract:
A number of studies have emphasised the diversity of motivations underlying different types of aggression tests in laboratory mica. An attempt was made to extend such considerations by studying the effects of gonadal hormones on a variety of models of aggression in Swiss albino mice. The treatments given included,- 1) Gonadeotomy for 7, 14 or 28 days 2) Replacement of castrates with 25, 50 and 100 ug of testosterone (T) for 7, 1 or 28 days; 3) Replacement with 0.1, 0.5 and 1.0 tag f oestradiol-17y (S) for 7, 14 or 28 days;4) Replacement with 50, 100 and 200 ug of 5aM hihydrotestosterone (5a mIT) for 7,14 or 28 days. The models used included the,- a) 'Standard opponent' test for social conflict; b) Maternal defense test; c) locust killing test; d) Electroshock induced attack test; and e) Tube restraint-induced biting test. The basic findings includes- i) Gonadectomy reduced and hormonal (T, T and501 DHT) replacement restored the attack in social conflict and electroshock induced situations. ii) Gonadectomy and 5j JET replacement had no influence but T and E replacements inhibited attack by lactating mice in the maternal defense test. iii) All the treatments mentioned above had no influence in locust killing and tube restraint induced test. Me data presented confirm that different models of 'aggression' (even in the am species) are modulatedby hormones in different ways. It is maintained that one should be cautious in extrapolating between different tests. This data is of especial importance in understanding the relationships between endocrinology and behaviour.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.637751  DOI: Not available
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