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Title: The synthesis of heterocyclic compounds related to natural products
Author: Hussain, A.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2001
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The thesis relates to the synthesis of heterocyclic compounds related to Natural Products. Chapter 1 deals with an introduction to hypervalent iodine reagents and their uses as phenolic oxidation reagents. The mechanism is also discussed. Chapter 2 concentrates on the production of 3-substituted phenols and the subsequent hypervalent iodine oxidation to see if a variety of chromenone compounds can be formed via intramolecular attack. Whilst not successful in generating the desired compounds, a number of oxidised products were isolated. Chapter 3 deals with making the 3-nucleophilic side chain on various phenols more rigid in the hope of aiding cyclisation. One reaction of note from this chapter was that an epoxide ring utilised, to give rigidity in the side chain, withstood the hypervalent iodine oxidation. Chapter 4 utilises the epoxide to bring rigidity to the 3-substituted side chain. All products bar one proved successful in generating their appropriate epoxychromenes, and that which didn't provided an alternative cyclised product. The final chapter deals with possible future work now that some success has been achieved.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available