Use this URL to cite or link to this record in EThOS:
Title: Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods
Author: Haggerty, K.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2001
Availability of Full Text:
Access from EThOS:
The use and analysis of the pesticidal study compounds are reviewed and the instrumental techniques of capillary electrophoresis (CE), mass spectrometry (MS) and high performance liquid chromatography (HPLC) are described. The quaternary ammonium herbicide Paraquat is amongst the most widely used herbicidal products worldwide. The technique of capillary zone electrophoresis (CZE) was evaluated as a means of separating paraquat from a mixture of related impurity compounds. The preconcentration technique of transient capillary isotachophoresis (tCITP) was examined as a means of improving detection limits. Both CZE and tCITP were used successfully in the analysis of technical paraquat. CE-MS was performed with varying levels of success. Flutriafol is a fungicidal compound widely used in the control of cereal diseases. HPLC methodology was developed for use in the separation of flutriafol from a mixture of related impurity compounds. The technique was successfully used in the analysis of a sample of production material with over 25 impurity peaks detected. HPLC-MS was performed and the use of SIM, SRM and CRM was investigated as a means of improving detection limits. HPLC-MS was used in the analysis of a production sample and over twenty peaks were detected in the total ion chromatogram (TIC). The mass spectral information obtained enabled the tentative identification of a number of impurities.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available