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Title: Genetic polymorphisms and cancer susceptibility database construction and analysis of genetic association studies
Author: Ye, Z.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2003
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The sequencing of the human genome and the ongoing discovery of single nucleotide polymorphisms (SNPs) provide us with new opportunities to understand the genetic basis for individual differences in susceptibility to disease, especially to cancer. Identification of individual's risk of developing cancer is a challenging goal of molecular epidemiology. In this thesis, a genetic polymorphism and cancer susceptibility database has been constructed and provided a valuable resource used to better understand individual cancer risk. Meta-analyses of cancer association studies give important clues for cancer risk assessment in molecular epidemiology. It can provide a systematic and quantitative approach to the summary of results from the different studies. This approach has been employed in my study to explore possible associations between the specific polymorphisms and cancer risk. Meanwhile, the associations between polymorphisms in the genes CYP1A1, GSTM1, GSTT1 and colon cancer risk in the UK population have also been examined in my study, EST analysis and laboratory studies approach were successfully employed to identify novel single nucleotide polymorphisms in the human p53R2 and Reprimo genes. My study gave strong evidence that EST analysis is a powerful tool for the detection of new polymorphisms in the human genome.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available