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Title: Studies on cyclic polyether analogues of peptides
Author: Williams, R. V.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2001
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Integrin antagonists have become attractive therapeutic targets in the last ten years. The work in this thesis describes the attempted synthesis of a novel crown ether based RGD peptidomimetic. Diol analogues of arginine, glycine and aspartic acid have been synthesised as precursors to the novel crown ether. It was found that small, polyfunctional molecules such as these were unstable under the basic conditions necessary for their incorporation into the crown ether. This work has involved extensive studies on the reduction and deamination reactions of orthogonally protected ornithine derivatives (notably α-hydroxy and α-silyloxy esters) and on the ring-opening reactions of β-hydroxy-γ-butyrolactone. As a background to this thesis, recent developments in integrins and integrin antagonists have been researched.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available