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Title: Foot Involvement in early Rheumatoid arthritis Study (FIRST) : a prospective ultrasound study
Author: Newcombe, Lisa Ward
Awarding Body: Glasgow Caledonian University
Current Institution: Glasgow Caledonian University
Date of Award: 2013
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Introduction: In early rheumatoid arthritis (RA), there is a known predilection for foot involvement, which has been shown to persist in patients in remission state. However, disease persistence and its impact on foot involvement in later disease is poorly understood, This is partly due to studies that limit assessment of inflammatory involvement to clinical and radiographic examination. High-resolution musculoskeletal ultrasound imaging is more sensitive and specific at detecting inflammation; however, research applied to the foot and ankle in the field is limited. The relationship between inflammatory and biomechanical factors leading to this persistence is further limited. The aim of this thesis was to improve understanding of disease persistence in the foot using a detailed description of the extent, severity and impact of ultrasound-detectable inflammation in the foot and ankles of patients with early RA, alongside global disease, gait and clinical metrics.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available