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Title: 3-D electromagnetic computational modelling of invasive and non-invasive hyperthermia techniques
Author: Clibbon, K. L.
Awarding Body: University College of Swansea
Current Institution: Swansea University
Date of Award: 1995
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The use of hyperthermia as an adjuvant treatment to existing cancer therapies such as radiation therapy or chemotherapy is well established. A problem common to all clinical hyperthermia applications is the lack of temperature information available during treatment. To lend understanding to these treatments, computational modelling of the electromagnetic interactions inducing heat within the tissues has been undertaken. The work carried out in this thesis develops predictive models for the power deposition from two hyperthermia techniques: an invasive method using interstitial microwave antenna arrays; and a non-invasive method employing surface current sheet applicators, incorporating the capabilities of existing electromagnetic models and the new approaches developed in this thesis. Such models not only provide understanding of the power deposition during treatment, and hence a measure of the heating produced, but also provide analysis for the improvement of antenna/applicator design, thus improving clinical treatment methodologies. The thesis initially considers the interstitial antenna arrays, developing a model capable of solving the power deposition from an array of symmetric/asymmetric insulated antennas with arbitrary orientations and positions. An improved efficiency solution method is derived and evaluated. The scattering and absorption effects produced by insertion of such arrays within an inhomogeneous biological environment is incorporated using a conjugate gradient FFT solver, based on a spectral iterative technique. Investigations into arbitrary array orientations are carried out and new methods of power deposition control are subsequently proposed. The non-invasive current sheet applicators are approached in the same manner producing a model capable of simulating the power deposition from an array of arbitrarily orientated applicators overlying a highly inhomogeneous treatment volume.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available