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Title: A study of the distribution of 195m platinum-labelled cisplatin in tumours using single photon emission computed tomography
Author: Buckley, S. E.
Awarding Body: University of Wales Swansea
Current Institution: Swansea University
Date of Award: 2006
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The aim of the study was to develop a scintigraphic technique to quantify the uptake of cisplatin in tumours. This will allow the relationship between tumour uptake and outcome to be assessed and in future may lead to a diagnostic test which can predict patient response to chemotherapy. Platinum enriched with 194Pt was irradiated for four days in NRG’s TIRO 1 reactor, to produce 195mPt. Spectral analysis of the target was performed using a calibrated HpGe detector and its constituent radioisotopes identified as 195mPt, 199Au and 192Ir. Using the detector’s intrinsic efficiency calibration their activities were estimated to be 1049, 133 and 5.8 MBq respectively. The performance of the gamma camera was tested using quality control procedures recommended by IPEM and found to be satisfactory. A torso phantom was used to determine the MDL of 195mPt in a 2 cm diameter tumour using SPECT acquisitions (32 steps, 60 s per step). The MDL was found to be 8 ppm assuming an administered patient dose of 50 MBq and a total cisplatin dose of 105 mg. Acquisitions were attenuation corrected using the Chang method. A broad beam attenuation coefficient of 0.18 cm-1, estimated using 201T1C1, was used. The measured system sensitivity was (20.5±0.5) cps/MBq. This technique consistently underestimated the activity in the organs of interest; this could be due to uncertainties in the activity calculated during spectral analysis or the technique itself. This work indicates that 195mPt -cisplatin is suitable for clinical scintigraphy and has led to the development of a clinical protocol that has been approved for a pilot study.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available