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Title: Investigations of secondary metabolites from Fijian marine sponges
Author: Tabudravu, Jioji N.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2001
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The following thesis presents results from investigations of marine natural products. It is divided into 7 chapters consisting of an introduction, five chapters examining the metabolites from Fijian marine sponges and one chapter examining the secondary metabolites from the medicinal plant, kava {Piper methysticum). Two new psammaplins (psammaplin K and L), a new isomalabaricane triterpene monosaccharide, two new bromotyrosine alkaloids (purealidin S and purpureamine J) and two new cyclic peptides (axinellin C and wainunuamide), a new conformer of phakellistatin 2 together with other known secondary metabolites were isolated from marine sponges. The new conformer of phakellistatin 2 was observed to adopt another conformation in CDCI3. Psammaplin A was found to inhibit chitinase from a Bacillus sp. and Serratia marcescens. The mode of activity was investigated by enzyme reaction kinetics and supported by X-ray crystallography. A new isomer of flavokavain A, woflavokavain A was isolated from kava, together with 7 known compounds. Solution conformations of axinellin C, jasplakinolide, phakellistatin 2 and its two conformers were generated using nOe restrained molecular modelling techniques.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available