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Title: Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
Author: Blundell, Katie Laura Irene May
ISNI:       0000 0004 5358 0918
Awarding Body: University of Essex
Current Institution: University of Essex
Date of Award: 2014
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Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part of an operon that contains two other genes predicted to handle cellular copper. This thesis reports first on the Sco-like protein from Streptomyces lividans (Sco sl) and presents a series of experiments that firmly establish a role for Sco sl as a copper metallochaperone as opposed to a role as a thiol-disulfide oxidoreductase that has been assigned to other bacterial Sco proteins.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available