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Title: Associations of genetic polymorphisms with health and behaviour in man
Author: Azimi-Garakani, C.
Awarding Body: University College of Swansea
Current Institution: Swansea University
Date of Award: 1982
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This study consisted of two parts, one of which discusses the effect of blood group polymorphisms on patterns of health, and the other reveals an association between tongue-rolling phenotypes with behaviour. In the first part, a random sample of 3427 newborn babies from two Cardiff hospitals was assayed for the ABO, MN, and Rhesus blood group systems. The observed heterogeneity resulting from the admixture of populations of different geographical variation was found to be removed if babies born to two overseas born parents were taken out of the analysis. After the exclusion of these babies the population characteristics for all blood group systems are seen to be similar to those previously recorded for Wales and for other parts of the U.K. Possible associations between phenotypic or genotypic distributions at individual loci and 18 birth variables during the first 28 days of life were sought for. A total of 54 tables was compiled and analysed by a series of X2 tests, of which 7 showed results significant at the 5% level, and 1 test showed a probability of between 5% and 10%. Chance alone would predict 2.7 significant associations. Significant results were detected between ABO phenotypes and: socio-economic class (P = 0.016), smoking habits during pregnancy (P = 0.010), maternal age (P = 0.013), toxaemia of pregnancy (P = 0.032), maternal labour complications (P = 0.031), and birth weight (P = 0.048); and between MN phenotypes and maternal labour complications (P = 0.029). The first 3 of these associations might be real, especially that concerned with smoking habits, which needs to be investigated further; but the remaining associations seem likely to be statistical artifacts. Generally negative results indicate that the genetic variation studied here is selectively neutral rather than adaptive. Confirmation of the probable heterozygote advantage in the MN system was looked for, but was not established. However, the observed excess of MN and AB blood groups in the total sample needs to be studied further. In the second part of this study, the distribution of tongue-rolling phenotypes in 1066 students in Swansea shows no difference between the sexes, but large differences between those studying Life Sciences and Arts. There are also indications of a difference in distribution between Arts students living in halls of residence and those living elsewhere. These data suggest that the loci governing this character may also contribute to variation in personality characteristics which influence choice of subject of study. Associations of socio-economic class, smoking habits, maternal age, birth weight, and sex of infant, with different birth variables were investigated. A total of 74 tables were analysed, of which 50 showed P < 0.0001, and 9 showed 0.0003 < P <0.05. The significance of these findings is discussed in the Appendix.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available