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Title: Studies on the effects of experimental manipulation on a variety of 'aggressive' behaviours in laboratory albino mice
Author: Al-Maliki, S. J.
Awarding Body: University College of Swansea
Current Institution: Swansea University
Date of Award: 1980
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Many of the early studies have emphasized the diverse nature of different forms of attack. Consequently, approximately 2,600 male and female 'To' strain mice, rendered aggressive by a variety of methods, were employed to examine the extent to which one can regard aggression as a non-unitary concept in this species. Experimental manipulations systematically employed throughout included: i) Situational factors such as housing condition, social status, sex of intruder, anosmia, stage of lactation, presence of young, presence of mate, sex of resident and age of resident; ii) Experience and selection of performance levels on different forms of aggression; iii) Food deprivation; iv) hormonal manipulations (effects of castration and treatment with dexamethasone and ACTII); v) Lithium chloride injection. Models of aggression investigated included: 1) Social aggression: fighting between non-habituated male mice; 2) Predatory aggression: attack on a locust; 3) Maternal aggression: attack by lactating mouse on a conspecific. 4) Electroshock-induced aggression; 5) Tube restraint-induced aggression: biting on an inanimate target by mice confined in a narrow tube. Basic findings included: A) that social aggression in isolated and mated males, and electroshock-induced aggression are generally manipulated by similar experimental factors. There was only slight evidence (from bite target studies) that the electroshock-induced attack is defensive. B) Maternal aggression in very situation-dependent and differs in its physiological control from the above. It appears to be a defensive response. C) Locust-killing is unlike the other types of aggression. D) Tube-restraint-induced aggression is rather different from the other forms of attack: a few experimental manipulations seemed to alter this activity. Consequently, one can confirm that aggression is not a unitary concept even in a single strain of mouse. Different responses seem likely to have different physiologies and workers should emphasise which form of attack they are looking at before attempting to make general statements about 'aggression'.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available