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Title: Genetic basis of hereditary persistence of fetal haemoglobin
Author: Gallienne, Alice E.
Awarding Body: Oxford Brookes University
Current Institution: Oxford Brookes University
Date of Award: 2013
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This thesis investigated the extent to which genetic factors underlie the variations observed in fetal haemoglobin (HbF) levels. This is important as it is known that an elevated HbF level can ameliorate the symptoms of many of the haemoglobinopathies. The frequency and range of hereditary persistence of fetal haemoglobin (HPFH) in the UK population was determined which was otherwise unknown. All 4 categories of deletion mutations were identified and demonstrated the high frequency of deletional HPFH in UK patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available