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Title: A role for p38δ MAPK in the pathogenesis of rheumatoid arthritis
Author: Jones-Phillips, Dominic
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2013
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Rheumatoid Arthritis (RA) is a chronic systemic auto immune disease characterised by progressive joint destruction and severe morbidity. Therapeutic treatment of RA has made several important advancements in recent years, with the advent of anti-TNF biologics, and yet non-response and heterogeneity of response to treatment is a constant hurdle to the development of new therapies. Anti-IL-6 receptor A antibody, tocilizumab, has had considerable success in patients refractory to anti-TNF therapies This report investigates the IL-6 pathway in RA and a potential role for p38δ MAPK in driving IL-6 expression via hypoxia-induced mechanisms.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available