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Title: Mechanistic studies of the amyloid precursor protein intracellular domain (AICO) with implications for Alzheimer's disease
Author: Beckett, Caroline
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2013
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Proteolytic cleavage of the amyloid precursor protein (APP) by the successive actions of [beta]- and [gamma] secretases produces amyloid-B-peptide (AB), the principal constituent of plaques in Alzheimer's disease (AD). In AD research, therapeutic strategies have heavily focussed on modifying the formation, aggregation and removal of AB. Yet, two decades on, available treatments remain limited and they are palliative, rather than disease modifying. Despite its major importance, the normal physiology of APP, its isoforms and its other biologically active metabolites remain largely unknown. The aim of this study was to investigate the role of the APP intracellular domain (AICD). By analogy with the Notch signalling pathway, AI CD has been proposed to have transcriptional activity although its mechanism of action and the complement of genes regulated remain controversial.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available